Ideal skin care cream for burns and wounds Compatible with all types of skin
For all age groups

Composition of Marigold Cream

  • Marigold Extract 10%
  • Liquid paraffin
  • Purified water

Pharmacology of Marigold

Calendic acid is the omega-6 fatty acid chain present in marigold which is one of the factors that gives its medicinal properties.

The principal identified constituents of calendula are triterpenoids and flavonoids. At least eight bioactive triterpendiol monoesters have been identified in the extracts of dried calendula flowers.


Wound healing

The wound healing process involves several distinct phases in which the formation of new blood vessels plays important role. In vivo, accelerated healing of wounds after treatment with calendula flower preparations has been demonstrated.  It has been proposed that Calendula officinalis extract may aid in wound healing by promoting epithelial growth and by enhancing immune responses. Rao et al. observed a reduction of epithelialization time, an increase in wound strength, and improvement of wound contraction in rats with experimental incision wounds that were topically treated with calendula. The effects may also be mediated by the stimulation of phagocytosis, by increased granulation, and via effects on metabolism of glycoproteins, nucleoproteins, and collagen proteins in tissue regeneration.

Complete cicatrization of experimental wounds in rabbits was achieved in 14 days with dry alcoholic extract of calendula flower, applied topically as a 10% hydrogel or 10%powder (in lactose), compared to 18-19 days with vehicle-only controls.

Anti-inflammatory activity

Calendula flower extracts have exhibited anti-inflammatory activity in several tests when  applied topically. The active components of calendula's anti-inflammatory activity are thought to be the triterpenoids, particularly faradiol monoester. Free ester faradiol is the most active and exhibits the same effects as an equimolar dose of indomethacin. In one study, the aromatic moieties of the triterpenes were chemically modified to increase anti-inflammatory activity in vivo. Calendula's glycosides have also inhibited lipooxygenase activity in vitro.

Antioxidant effects

Extracts of Calendula officinalis have anti-oxidant activity and demonstrate strong abilities to scavenge reactive oxygen species. Plants of the genus Calendula are natural sources of betacarotene, which may contribute to potential antioxidant effects. Nineteen carotenoids have been identified in extracts of Calendula officinalis petals, including flavoxanthin and isomers of lycopene, carotene, and rubixanthin.


  • Anti – inflammatory
  • Re-epithelizing properties (wound healing)
  • Antimicrobial (ant-viral, anti-fungal & anti-bacterial)
  • Antiseptic action
  • Humectants properties
  • Astringent - treating minor cuts and burns.
  • Antioxidant


  • Marigold cream being a herbal remedy it is ideal for sensitive and dry skin.
  • Marigold cream easily blends/melts into the skin and penetrates quickly.
  • Cream can be applied to areas where maximum protection is vital such as the skin that has drainage, skin fold and sensitive areas
  • It is ideal for all age groups.
  • It has good safety profile and better tolerability on skin

Mechanism of Action

Marigold cream contains chemical constituent which speed up wound-healing by several actions that include:

Increasing blood flow and oxygen to the affected area and promoting the production of collagen proteins which helps wounds heal faster by improving neo vascularisation in tissue or in simple terms the growth of new small capillaries, (the body grow new tissue) that then improve blood circulation.

Dosage and Application

  • Cream is applied in very small quantity, as a thin layer on the affected area.
  • Apply several times a day on the affected areas.

All about Marigold Flower

A popular garden plant, Marigold has been valued for many centuries for its' exceptional healing powers and is particularly remarkable in the treatment of wounds.  It is an annual plant that thrives in almost any soil. It belongs to the same family as daisies, chrysanthemums and ragweed. When used for medicinal purposes, it is commonly referred to as 'Calendula'.

In appearance, Marigold looks like a large yellow or orange colored daisy, each floret being about ½" (1.25cm) long. A hardy annual, the plant produces its' bright flowers throughout the summer and the flower heads may grow up to 3" (7cm) in diameter. Marigolds' simple fruits are closely curled in the middle of the flower head, almost in the form of a ring. Hence in Germany, its' common name is ringelblume, meaning ringed flower.

The plant grows to a height of approximately 20-28" (50-70cm). The stem is erect and branched, bearing alternate, light green, lance-shaped leaves and both stem and leaves are covered with fine hair. Marigold is described by some as without a marked scent, but others find its' odour rather heavy, while its' taste is bitter. Marigold is self-seeding and once planted, it largely takes care of itself. It thrives in a sunny position and will grow in any good soil, though it prefers one that is rich and moist.

The dried flower petals (orange-yellow) of the marigold/ pot marigold plant have been used for medicinal purposes since at least the 12th century. Traditionally, it has been used to treat conjunctivitis, blepharitis, eczema, gastritis, minor burns including sunburns, warts, minor injuries such as sprains & wounds. It has also been used to treat cramps, coughs, and snake bites.

The Romans discovered that marigold bloomed on the first day of each month, and, therefore, named it for the calendar thus, the Latin term, Calendula officinalis. Officinalis is the word to indicate official medical abilities as accepted in a pharmacopeia.

Learn about your Skin

The skin is the largest organ of the body, with a total area of about 20 square feet. The skin protects us from microbes and the elements, helps regulate body temperature, and permits the sensations of touch, heat, and cold.

Skin has three layers:

  1. The epidermis, the outermost layer of skin, provides a waterproof barrier and creates our skin tone.
  2. The dermis, beneath the epidermis, contains tough connective tissue, hair follicles, and sweat glands.
  3. The deeper subcutaneous tissue (hypodermis) is made of fat and connective tissue.

The skin’s color is created by special cells called melanocytes, which produce the pigment melanin. Melanocytes are located in the epidermis.

Function of Skin

  • Cover- protects from germs, dehydration, injury etc. First line of defense
  • Regulates body temperature
  • Manufactures vitamin D
  • Site of many nerve endings
  • Temporary storage of glucose, fat, water and salt.
  • Protects from UV radiation
  • Can absorb chemical substances
    • Nitroglycerin patch
    • Ointment for rashes

Diseases of the Skin

  • Acne - A common and chronic disorder of the sebaceous glands.
  • Warts - Small, rough growth, typically on a human’s hands or feet caused by a viral infection
  • Cysts - Closed sac, may contain air/ fluids/ semi-solid material
  • Eczema - Inflammation of the epidermis (the outer layer of the skin)
  • Seborrhea - Inflammatory skin disorder affecting the scalp, face, and torso
  • Hemorrhoids - Vascular structures in the anal canal, painful when swollen or inflamed
  • Impetigo -  Highly contagious bacterial skin infection most common among pre-school children
  • Peeling skin -  (Desquamation) shedding of the outermost membrane or layer of a tissue
  • Oily skin - Lead to acne flare-ups due to larger pores
  • Mastitis –  Inflammation of breast tissue
  • Burns - Type of injury to skin caused by heat, electricity, chemicals, light radiation or friction (most burns effect only the skin – epidermal tissue)
  • Rashes – Change in the skin which affects its color, appearance or texture
  • Bruises - Also called a contusion in which capillaries and sometimes venules are damaged by trauma, allowing blood to seep, hemorrhage, or extravagate into the surrounding interstitial tissues
  • Insect Bites – occur when an insect is agitated and seeks to defend itself through its natural defense mechanisms, or when an insect seeks to feed off the bitten person,  are usually painful and itchy
  • Cuts & wounds - a type of injury in which skin is torn, cut, or punctured In pathology, it specifically refers to a sharp injury which damages the dermis of the skin


Head Office -
Telephone  +387 030 515 005
Address – Pharmamed d.o.o,
Dolac na Lašvi bb 72270 Travnik, Bosnia and Herzegovina

Dubai Office
Regional Pharma Trading DMCC
P. O. Box - 487455
Dubai, UAE

Tel : +971 444 860 01
Fax : +971 444 860 02

Email :